Superfusion组织表面灌注系统的描述

HSE—HA生理学系统是一系列应用广泛的完备产品，可用于整体动物生理学、立体或在体器官和组织灌注及组织浴槽研究。这些系统具有广泛的应用，包括传统的安全药理学、DMPK、毒理学、呼吸系统、心脏病学、分子生物学和生理学。每个系统都设计了标准的组件，再加一些其他配置以适合特殊研究的需要。。标注组件也意味着如果你是需要将现有设备配齐，或者进行系统升级，或者是完整的配套产品，你都只需要购买需要的构件。HSE-HA生理学系统为你提供各种工具，使你的研究走向多产和成功。

我们提供大多数生理学检测设备，包括放大器、电极、传感器和电化学检测器。参数包括力、位移、压力、液体和气体流、心电图（单导联—12导统）、MAP（单个或多个部位）、脑电图、*、连续支流灌注传统的血气参数和电解质的分析，可以选择程序化软件和传统的刺激器作为放大器、电极和传感器等产品的补充。

HSE-DAQ系统产品家族（BDAS、ACAD、HAEMODYN、ISOHEART、PULMODYN、PENNOCK）可以记录你的初始信号，计算到处的参数，注释数据，快速简易的输入确定的数据用于分析。同时还可以选择用于进一步分析的软件模块，带状记录纸打印，自动和控制模块等。产品经过预先设置，打开包装即可使用，并专门设计符合你的系统配置和数据分析要求。

• Applications:

– Evaluation of metabolites or mediators released on subsequent tissues in the fluid cascade

– Detection of substances affecting the smooth musculature （prostaglandins, bradykinin, angiotension II...）

• Suitable for colon, bladder, ileum, duodenum, aortic strips...

• Low volume superfusion is useful when only small quantities of drugs are available

• No contact with glass, surface-active substances cannot be absorbed on the glass surface and contaminate results

The Superfusion Cascade Bath permits testing of extremely small quantities of pharmaceuticals. Any metabolites or mediators released are passed to the subsequent test preparation and can become effective there. It is possible to test up to four preparations （muscle strips or isolated tissues）. The preparations are contained in a thermostated chamber. A roller pump produces a small flow of solution （1 – 10 ml/min） which is warmed by a heat exchanger then drips on to the uppermost test preparation. There is a provision for switching between two different solutions. The effluate of each preparation passes in the form of a cascade onto the subsequent preparation. Any muscle contractions produced are measured by force transducers （isometric contraction measurement） or displacement transducers （isotonic contraction measurement）.

The Superfusion Cascade Bath, as modified by SCHULER, consists of a moist acrylate chamber which is thermostated by radiant heat from a thermostated metal plate. Temperature control is provided by a thermostatic circulator. The four tissues are arranged in cascade so that each tissue receives its superfusion solution from the previous tissue through a small tube. These stainless steel tubes carry a ring to which the tissues are attached. Part of the tube is in the form of an open channel. The tubes can be moved in height （vertically） and also horizontally, ensuring optimum adjustment to suit the suspended tissues and allows superfusion free from any interruption. Mounting the tissues is simplified by the removable front panel of the chamber.