coleman组织表面灌注系统的描述

HSE—HA生理学系统是一系列应用广泛的完备产品，可用于整体动物生理学、立体或在体器官和组织灌注及组织浴槽研究。这些系统具有广泛的应用，包括传统的安全药理学、DMPK、毒理学、呼吸系统、心脏病学、分子生物学和生理学。每个系统都设计了标准的组件，再加一些其他配置以适合特殊研究的需要。。标注组件也意味着如果你是需要将现有设备配齐，或者进行系统升级，或者是完整的配套产品，你都只需要购买需要的构件。HSE-HA生理学系统为你提供各种工具，使你的研究走向多产和成功。

我们提供大多数生理学检测设备，包括放大器、电极、传感器和电化学检测器。参数包括力、位移、压力、液体和气体流、心电图（单导联—12导统）、MAP（单个或多个部位）、脑电图、*、连续支流灌注传统的血气参数和电解质的分析，可以选择程序化软件和传统的刺激器作为放大器、电极和传感器等产品的补充。

HSE-DAQ系统产品家族（BDAS、ACAD、HAEMODYN、ISOHEART、PULMODYN、PENNOCK）可以记录你的初始信号，计算到处的参数，注释数据，快速简易的输入确定的数据用于分析。同时还可以选择用于进一步分析的软件模块，带状记录纸打印，自动和控制模块等。产品经过预先设置，打开包装即可使用，并专门设计符合你的系统配置和数据分析要求。

• Applications:

– Evaluation of the potency of labile substances

– Determining the rates of onset and offset of drug action

– Evaluation of spasmogenic and spasmolitic agents

• Compact, allows the study of up to four tissue preparations in parallel

• Rapid removal of potentially toxic metabolites

• Obviates the necessity of repeated washing procedures

• Rates of onset and offset of drug action are easily measured

In the Coleman Superfusion Bath, the tissue is located in a horizontally split chamber. The lower part of the chamber can be swung away to simplify access to the preparation. The lower end of the tissue is held by a stainless steel hook. The thread attached to the top of the tissue passes through an opening at the top of the chamber for direct to the force transducer. The superfusion solution is fed by a multi-channel roller pump through a stainless steel cannula to the thread and it runs down the thread and superfuses the tissue. Two separate solution paths are available for superfusion with and without test substance. Two platinum wires for field stimulation are placed parallel to the tissue to form the stimulation field. The solution running down provides electrical contact between the electrodes and the tissue. The superfusion vessels are made from an acrylate block and do not require thermostating owing to the low thermal conductivity of the material used.

The superfusion chambers are mounted on a horizontal support rod according to the number of channels required. A stand for 4-position superfusion system is available. The superfusate is thermostated immediay before entering the chamber by a two line heat exchanger supplied from a water thermostat. The heat exchanger is made of a tubing coil that can be easily replaced. A collecting trough is located underneath the superfusion chambers for collecting of the used solution; alternatively the superfusate can be collected from the chamber outlet for recirculation.