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| IL-4离体肺灌注系统的概述 HSE—HA生理学系统是一系列应用广泛的完备产品，可用于整体动物生理学、立体或在体器官和组织灌注及组织浴槽研究。这些系统具有广泛的应用，包括传统的安全药理学、DMPK、毒理学、呼吸系统、心脏病学、分子生物学和生理学。每个系统都设计了标准的组件，再加一些其他配置以适合特殊研究的需要。。标注组件也意味着如果你是需要将现有设备配齐，或者进行系统升级，或者是完整的配套产品，你都只需要购买需要的构件。HSE-HA生理学系统为你提供各种工具，使你的研究走向多产和成功。 我们提供大多数生理学检测设备，包括放大器、电极、传感器和电化学检测器。参数包括力、位移、压力、液体和气体流、心电图（单导联—12导统）、MAP（单个或多个部位）、脑电图、*、连续支流灌注传统的血气参数和电解质的分析，可以选择程序化软件和传统的刺激器作为放大器、电极和传感器等产品的补充。 HSE-DAQ系统产品家族（BDAS、ACAD、HAEMODYN、ISOHEART、PULMODYN、PENNOCK）可以记录你的初始信号，计算到处的参数，注释数据，快速简易的输入确定的数据用于分析。同时还可以选择用于进一步分析的软件模块，带状记录纸打印，自动和控制模块等。产品经过预先设置，打开包装即可使用，并专门设计符合你的系统配置和数据分析要求。
• Investigation of ventilation and perfusion in the isolated rabbit lung • Optimized in-situ preparation • Negative-pressure ventilation to mimic closely the in-vivo situation • Regular induction of hyperinflation of the lung （sigh） • Perfusion under constant flow condition using buffer solution or blood • Continuous measurement of lung mechanics （tidal volume, resistance, compliance）, and perfusate characteristics （pressure, pCO2, pO2, pH） • Continuous measurement of lung weight changes （Edema）
Ventilation When the lung is placed in the artificial thoracic chamber and ventilated at negative pressure, the ventilation head is removed and replaced by the pneumotachometer for the measurement of respiratory flow. The ventilation medium （air or gas mixture） is constantly flowing past the distal end of the pneumotachometer. The breathing frequency can be varied between 30 and 60 breaths/min. In addition, the inspiratory time as a percentage of each breath, can be set between 10 and 90% in 10% steps. The end-inspiratory, end-expiratory, and deep breath （hyperinflationary） negative pressure can be set individually. A deep breath is usually induced every 5 to 20 min. Constant Flow Perfusion The constant flow rate of perfusate into the pulmonary artery is determined by a roller pump. The perfusate is stored in a water-jacketed container to maintain constant temperature. Aeration is provided to keep the pH constant. A heat exchanger and a bubble trap are placed next to the pulmonary artery connection for exact adjustment of the perfusate temperature just before the thorax chamber and to prevent air bubbles entering the lung. Different perfusates can be provided in turn by transferring the suction tube from one reservoir to another; there is no need for prior aeration or temperature control. The use of oxygen-sensitive test substances raises few problems since the contact time with the high oxygen concentration is minimized. It is also possible to vary the gas mixture rapidly during the study. A Constant Pressure Perfusion System is optionally available. Please call for details. Lung Mechanics The pressure inside the thoracic chamber is measured with a MPX pressure transducer. Air flow is determined with the pneumotachometer connected to a Validyne differential pressure transducer DP 45-14. The volume is derived from the air flow by integration. The calculation of pulmonary compliance and resistance needs a computer controlled data acquisition system （HSE-HA Pulmodyn）. • Investigation of ventilation and perfusion in the isolated rabbit lung • Optimized in-situ preparation • Negative-pressure ventilation to mimic closely the in-vivo situation • Regular induction of hyperinflation of the lung （sigh） • Perfusion under constant flow condition using buffer solution or blood • Continuous measurement of lung mechanics （tidal volume, resistance, compliance）, and perfusate characteristics （pressure, pCO2, pO2, pH） • Continuous measurement of lung weight changes （Edema） |
