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Xcessbio Biosciences代理,Xcessbio Biosciences中国代理,Xcessbio Biosciences代理,Xcessbio Biosciences上海代理,Xcessbio Biosciences北京代理,M60237-2s广州代理,Xcessbio Biosciences,M60237-2s代理,L755,507, CRISPR Editing Enhance,Xcessbio Biosciences产品代理,Xcessbio Biosciences产品代理
A potent and selective β3 adrenergic receptor partial agonist, can enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
Catalog No. | Unit | Price | Qty |
---|---|---|---|
M60237-2s | 2 mg solid |
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Product Information M60237-2s代理,L755,507, CRISPR Editing Enhance
Molecular Weight: | 584.73 |
Formula: | C30H40N4O6S |
Purity: | ≥ 98% |
CAS#: | 159182-43-1 |
Solubility: | DMSO up to 100 mM |
Chemical Name: | (S)-4-(3-hexylureido)-N-(4-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide |
Storage: | Powder: 4oC 1 year DMSO: 4oC 3 month -20oC 1 year |
Biological Activity:M60237-2s代理,L755,507, CRISPR Editing Enhance
L-755,507 was previously characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 ~0.43 nM. It has > 1000 fold selectivity overβ1- and β2-adrenoceptors (EC50 ~ 580 nM and >10000 nM for β1- and β2-adrenoceptors respectively). It stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). In a recent study, L-755,507 was identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
How to Use:
In vitro: L-755,507 was used at 1-5 ?M final concentration in various in vitro assays.
In vivo: L-755,507 stimulates metabolic rate by 30% after acute bolus intravenous administration of 0.1 mg/kg to rhesus monkeys.
Reference:M60237-2s代理,L755,507, CRISPR Editing Enhance
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