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L755,507, CRISPR Editing Enhancer

A potent and selective β3 adrenergic receptor partial agonist, can enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.

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Product Information M60237-2s代理，L755,507, CRISPR Editing Enhance

Biological Activity:M60237-2s代理，L755,507, CRISPR Editing Enhance

L-755,507 was previously characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 ~0.43 nM.  It has > 1000 fold selectivity overβ1- and β2-adrenoceptors (EC50 ~ 580 nM and >10000 nM for β1- and β2-adrenoceptors respectively). It stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). In a recent study, L-755,507 was identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. 

How to Use:

In vitro:  L-755,507 was used at 1-5 ?M final concentration in various in vitro assays.

In vivo: L-755,507 stimulates metabolic rate by 30% after acute bolus intravenous administration of 0.1 mg/kg to rhesus monkeys.

Reference:M60237-2s代理，L755,507, CRISPR Editing Enhance

• 1.      Fisher MH, et al. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. (1998) J Clin Invest.101(11):2387-93.
• 2.      Parmee ER, et al. Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist. (1998) Bioorg Med Chem Lett. 8(9):1107-12.
• 3.    Yu C, et al. Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells. (2015) Cell Stem Cell.16(2):142-7. 

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